Organic synthesis preparation analysis of aspirin

What is their general structure? Esters are derivatives of organic acids carboxylic acidswhilst carboxylic acids contain the carboxyl group COOHin an ester the hydrogen is replaced by an alkyl group. Therefore they are said to be the result of a reaction between a carboxylic acid and an alcohol with water as a side product. Their general structure is:

Organic synthesis preparation analysis of aspirin

Bungabong Group 2 5L I. This aspect of organic chemistry has contributed much to the knowledge there is regarding the reactions undergone by the specific families of compounds.

Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials.

The objective of organic synthesis is to design the simplest synthetic routes to a molecule. Aspirin, is the common name for the compound acetylsalicylic acid, widely used to reduce fever and as a pain killer.

Nowadays, salicylic acid is administered in the form of aspirin which is less irritating to the stomach than salicylic acid. It is an acetyl derivative of salicylic acid.

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To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, phosphoric acid will be used as the catalyst.

The excess acetic acid will be quenched with the addition of water. McMurry, The aspirin product is not very soluble in water so the aspirin product will precipitate when water is added. Nucleophilic acyl substitution simply means the replacement of one nucleophile attached to a carbonyl group with another.

For the synthesis of aspirin from salicylic acid, the acyl component being nucleophilically substituted is acetic anhydride. The nucleophile attached to the acyl group that is being replaced is acetic acid, or acetate ion CH3COO- before protonation.

The newly formed nucleophile attacted to the acyl group is salicylic acid, the substrate that is being acylated. The synthesis reaction of aspirin is shown below: In this experiment, the crude product will be the desired product.

The percent yield of the crude product will be determined for this reaction. The purity of the product will also be analyzed Casey, Lastly, melting point is a property possessed by a certain compound.

The melting point range of pure aspirin is degree Celsius and the melting point range of the salicylic acid starting material is degree Celsius. If impurities are present in your crude sample, the melting point range for your product will be theoretically lower than the range of pure aspirin.

Organic synthesis preparation analysis of aspirin

Schematic Diagram of the Procedure 1. Characterization of Aspirin Pinch of aspirin -propose method of differentiation product from starting material -differentiate synthesized acetylsalicylic acid from commercial aspirin -dissolve in 2 mL H2O and 1 mL iodine solution; observe reaction 4.

Suction filtration setup Figure Melting Point Determination Set-up C.A GREENER APPROACH TO ASPIRIN SYNTHESIS Loupy, A. Microwaves in Organic Synthesis, 1st edition; Wiley-VCH Verlag GmbH & Company KGaA, Weinheim, , pp. 35, SIMULATION EXERCISE OF THE 1H NMR SPECTRUM OF ASPIRIN 1.

Perform a first order analysis of the 1H NMR spectrum of aspirin. () Experiment #4 1 Synthesis of Acetaminophen and Analysis of Some Common Analgesics Background In this experiment, p-acetamidophenol (acetaminophen) will be prepared from p- aminophenol by reaction with acetic anhydride.

Synthesis Analysis Of Aspirin Lab Answers. The preparation of aspirin. PREPARATION OF ACETYLSALICYLIC ACID (ASPIRIN) The Aspirin Synthesis Reaction Aspirin is known to be unstable in the presence of moisture at elevated.

Abstract: The synthesis of aspirin is a part of many undergraduate organic synthesis labs and is frequently used in qualitative organic analysis laboratory for the identification of salicylic acid. We have found that aspirin can be synthesized on microscale by a. A study guide for the synthesis of aspirin.

Ideal for students taking CHEM 40 or Organic Chemistry who are doing their pre-laboratory and post-laboratory reports with the said experiment. preparation of Aspirin.

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Synthesis and Characterization of Aspirin. Aspirin Synthesis and Analysis. Experiment 9 in Beran page to Prelab = Page. The Synthesis of Organic AspirinAbstract:The purpose of this experiment was to find out how a reaction undergoes for a globally known painkiller called aspirin, and to become familiar with achieving successful yields.

Aspirin is synthesized from salicy 5/5(1).

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